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Professor Yuh-Chang Sun

NTHU CoNS Research Opportunities

Principal Investigator


Yuh-chang Sun




886-3-5757131 ext 35596



Research Interests

Chemical trace element analysis is a many-faceted and important issue. The ongoing progress of science has shown that it is important for analytical scientists to determine not only the presence of particular elements but also their species (such as different chemical forms and metal-based nanoparticles). There are many fields where this is applicable and where there are a number of topics to be addressed. In the past decade, the understanding of the impact of various species of trace elements on biological and environmental systems has been remarkably advanced, due mainly to the significant improvement in the analytical techniques. Apart from the problems associated with the extremely low concentrations of desired elements and their species in biological and environmental systems, attaining satisfactory degrees of trace analytical task requires the development of more compact and rapid analytical methodologies and spurs on research into hyphenated analytical techniques. To overcome the challenges described above, the development and initiation of novel and highly sensitive hyphenation techniques for trace determination/element speciation in key areas of chemical analysis are the main tasks in our lab.

Recent Research Highlights

Development of hyphenated systems to determine trace elements and their species in environmental and biological samples

Development of on-line and miniaturized hyphenated systems for in-vivo determination of the dynamic variation of metal ions and nanoparticles in target organs

Development of ultrasensitive nano-based analytical techniques

Honors and Awards

2010  Best poster prize from 4th Asia-Pacific Winter Conference on Plasma Spectrochemistry, Nov. 16, Chengdu, China.

2013  Best poster prize from 12th Asian Conference on Analytical Sciences (ASIANALYSIS XII), Aug. 22, Fukuoka,  Japan.

2013  Best poster prize from 2013 Annual Meeting of Chemistry Society in Taipei, Nov. 22, Nantao, Taiwan.

Tsing Hua Distinguished Professor, National Tsing Hua University, Taiwan

Selected Publications

1. Using Copper Ions to Amplify ROS-Mediated Fluorescence for Continuous Online Monitoring of Extracellular Glucose in Living Rat Brain, Biosens. Bioelectron. 2015, 64, 535–541.


2. Quantitatively Profiling the Dissolution and Redistribution of Silver Nanoparticles in Living Rats Using a Knotted Reactor-Based Differentiation Scheme, Anal. Chem. 2014, 86, 8267–8274.


3. Development of a Titanium Dioxide-Coated Microfluidic-Based Photocatalyst-Assisted Reduction Device to Couple High-Performance Liquid Chromatography with Inductively Coupled Plasma-Mass      Spectrometry for Determination of Inorganic Selenium Species, Anal. Chem. 2013, 85, 10091–10098.


4. Chemically Differentiating Ascorbate-Mediated Dissolution of Quantum Dots in Cell Culture Media, Nanoscale 2013, 5, 2073–2079.


5. Gold-Nanoparticle-Based Graphite Furnace Atomic Absorption Spectrometry Amplification and Magnetic Separation Method for Sensitive Detection of Mercuric Ions, Biosens. Bioelectron. 2011, 11, 4605–4609.


6. In Vivo Monitoring of Quantum Dots in the Extracellular Space Using Push-Pull Perfusion Sampling, Online In-Tube Solid Phase Extraction, and Inductively Coupled Plasma Mass Spectrometry, Anal. Chem. 2010, 82, 7096–7102.


7. In Vivo Monitoring of the Transfer Kinetics of Trace Elements in Animal Brains with Hyphenated Inductively Coupled Plasma Mass Spectrometry Techniques, Mass Spectrom. Rev. 2010, 259, 392–424.


8. Online In-Tube Solid-Phase Extraction Using a Nonfunctionalized PVC Tube Coupled with ICPMS for in Vivo Monitoring of Trace Metals in Rat Brain Microdialysates,  Anal. Chem. 2008, 80, 6959–6967.


9. In Vivo Monitoring of Multiple Trace Metals in the Brain Extracellular Fluid of Anesthetized Rats by Microdialysis-Membrane Desalter-ICPMS, Anal. Chem. 2007, 79, 8900-8910.


10. On-Line HPLC-UV/Nano-TiO2-ICPMS System for the Determination of Inorganic Selenium Species, Anal. Chem. 2006, 78, 2640–2645.


Graduate Student Researcher Openings and Requirements





Salary: depending on academic and research performance

Type I

Type II

Type III

Tuition waiver + $550/month

Tuition waiver + $300/month



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